This research investigated the hepatoprotective activity role of polyherbal formulation in paracetamol-induced hepatotoxic male albino rats, including assessement of acute toxicity evaluation. Divided into five classes (n=6) were albino rats (200-250g). The paracetamol (PCM) was diluted with saline (vehicle) before oral administration (o.p). Antioxidant enzyme activities, for example lipid peroxidants, reduced testing of glutathione and liver function was evaluated. Polyherbal formulation was administered orally at dose upto 5000 mg/kg body weight acute toxicity assessment. In acute toxicity study, no mortality reported in polyherbal formulation (PHF). Paracetamol was used as toxic agent in present study and the protective effect of Polyherbal formulation against the PCM-induced hepatotoxicity was studied. The extent of toxicity was estimated by histopathological tests and biochemical enzyme markers such as ALT, AST, ALP and SB have measured the level of toxicity and the findings have been contrasted with standard drug silymarin. The present study reports possible hepatoprotective activity of polyherbal formulation (PHF) against hepatic injury produced by paracetamol in albino rats. Polyherbal formulated flavonoids (PHF) may be responsible for the pronounced hepatoprotective effects found in this report.
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